On September 24, 2020, the U.S. Food and Drug Administration (FDA) presented a  warning to the public about serious problems with high doses of the first-generation antihistamine diphenhydramine (Benadryl), which can lead to heart problems, seizures, coma, or even death. Teens have been taken to emergency departments, and some have died after participating in the “Benadryl Challenge” on the popular social media platform TikTok.

Consumers, parents, and caregivers are being cautioned to store diphenhydramine and all other OTC and prescription medicines out of children’s reach and sight. FDA recommends parents lock up medicines to prevent accidental poisonings by children and misuse by teens, especially when they are home more often due to the COVID-19 pandemic and may be more likely to experiment.